Killer blows? Knockout study of pair of mouse MicroRNA provides cancer insight

(Tokyo Medical and Dental University) Tokyo Medical and Dental University (TMDU) researchers used knockout mouse models created by gene editing to reveal that the miRNA miR-146b, like miR-146a, is involved in the development of cancers, with them having similar but not identical effects. The knockout mice showed high rates of B-cell lymphoma and acute myeloid leukemia, which was associated with the absence of miRNA causing NF-κB overactivation. These insights should help in the fight against cancers involving miRNA dysregulation.
Source: EurekAlert! - Biology - Category: Biology Source Type: news