Follicular fluid progesterone level associated with fertilization outcome during in vitro fertilization: a systematic review and meta-analysis

Publication date: Available online 17 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Bernadett Nagy, Laszlo Poto, Nelli Farkas, Miklos Koppan, Akos Varnagy, Kalman Kovacs, Szilard Papp, Noemi Bohonyi, Jozsef BodisAbstractFollicular fluid (FF) is a key biochemical environment for oocyte development. The potential effect of follicular progesterone level on successful fertilization is a subject of debate, therefore our aim was to give a summary on the currently available evidence on the association between FF progesterone level and fertilization outcome.To do so, a systematic review and a meta-analysis were performed, with the literature searches being conducted in three databases (PubMed, EMBASE and The Cochrane Library) to identify all relevant studies ever published up till 19 August 2017. Data was available from 13 studies (4 ICSI and 9 conventional IVF) and 1009 individually aspirated FF samples were included in the analysis. The progesterone levels in FF were significantly higher in normal fertilization than in failed fertilization, both in conventional IVF (33 % difference, p
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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ConclusionAfro-Caribbean women receiving infertility care in the Caribbean may have better ART outcomes compared to African-American women in the United States (US).
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh+/ −, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.MethodsA total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh+/ −, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromoso...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionThis study concurs with the recent data suggesting that employing ICSI solely for teratospermia is unnecessary. This may allow clinics to decrease ICSI rates without sacrificing success rates, leading to lower cost and risk associated with treatment.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Conclusion(s): The combined Stop GnRH-ag/GnRH-ant COH protocol is a valuable tool in the armamentarium for treating “genuine” poor ovarian responders. Further, large prospective studies are needed to elucidate its role in POR and to characterize the appropriate patients subgroup (before initiating ovarian stimulation) that may benefit from the combined Stop GnRH-ag/GnRH-ant COH protocol.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: May 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 5Author(s): Lan Wang, Wen Yao, Xianan Tang, Haixia Yao, Sheng Wei, Jiao Huang, Ben Willem J Mol, Lei Jin, Jing Yue, Rui Wang
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Publication date: May 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 5Author(s): Meritxell Jodar, Claudio Attardo-Parrinello, Ada Soler-Ventura, Ferran Barrachina, David Delgado-Dueñas, Salvadora Cívico, Josep Maria Calafell, Josep Lluís Ballescà, Rafael Oliva
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
We report the following outcomes: (1) live birth rates in AID and IVF-D treatment for couples with severe male infertility factors and prior ICSI failures; (2) paternal impact on embryo development of the same oocyte cohort; (3) prognostic factors in obtaining a live birth with donor semen.ResultsOf 92 women with failed ICSI cycles (26 with multiple attempts), 45 couples underwent AID treatment. Live birth rate per cycle of AID was 18.9%. Fifty-three patients underwent IVF-D including 6 couples who previously did not conceive with AID. Embryological outcomes including fertilization, viable cleavage embryos, and blastocyst ...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionOverall, this study offers new insight on AMH effects upon cumulus cells and new aspects on how AMH might promote oocyte integrity and embryo viability at a biochemical level as well as add to the current body of evidence supporting AMH clinical potential as a more sensitive marker ofIVF outcomes in comparison with FSH, regarding numbers of oocytes received and high-quality day 2 and day 3 embryos.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
AbstractPurposeTo explore the effects of traditional vs. intracytoplasmic sperm injection (ICSI) insemination method on the outcome of high-quality blastocyst development in a split sibling oocyte cohort.MethodsIn this retrospective cohort study, we analyzed 62 ICSI/IVF split cycles. Sibling oocytes were randomly assigned to ICSI or IVF insemination. Two hundred thirty-four ICSI-only cycles and 152 IVF-only cycles were also analyzed for comparison. Blastocysts were graded by Gardner ’s embryo grading and were considered a high-quality blastocyst if 3BB or better (Gardner1999).ResultsIn the ICSI/IVF split group, (1) I...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Abstract This was a cohort study of in vitro fertilization (IVF) subjects at the University of Utah, Salt Lake City (UT, USA) utilizing partner sperm. Cycles where both the hamster egg penetration test (HEPT) and semen analysis were performed within 2 years prior to IVF cycles were stratified into four groups based on a normal or an abnormal HEPT and morphology. The mean conventional and intracytoplasmic sperm injection (ICSI) fertilization rates were calculated in each group. We performed a univariate analysis on the primary outcome comparing clinically interesting subjects. We performed a cost-effectiveness anal...
Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
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