Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add?

AbstractPurpose of ReviewPrevious trials definitively established that lowering systolic blood pressure (BP) to 140  mmHg prevented heart failure (HF) exacerbations, but the potential benefits and risks of further BP reduction remain unclear due to a paucity of trial-based data.Recent FindingsA recent secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) found that in older, high-risk, non-diabetic participants with systolic hypertension, a BP treatment target<  120 mmHg resulted in a 36% lower rate of acute decompensated HF as compared with a BP target<  140 mmHg. Those participants with incident HF had a 26-fold increased risk of subsequent cardiovascular events and death. Based in part on the SPRINT results, the 2017 American Heart Association/American College of Cardiology/HF Society Guideline for the Management of HF acknowledged that target ing a significant reduction in BP in those at increased risk for cardiovascular disease is a novel risk-based strategy to prevent HF.SummarySPRINT redefines systolic BP target goals in older, high-risk patients and provides a key opportunity for preventing HF in this patient group.

Source: Current Hypertension Reports - January 18, 2019 Category: Primary Care Source Type: research