BRCA mutation screening and patterns among high-risk Lebanese subjects

ConclusionTheBRCA1 c.131G  >  T mutation can be considered a founder mutation in the Lebanese population detected among 5/17 (29%) of individuals diagnosed with a mutation inBRCA1 and among 7/269 families in this cohort. On review of recently published data regarding the landscape ofBRCA mutations in the Middle East and North Africa, each region appears to have a unique spectrum of mutations.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research