A Comment on the Diagnosis and Definition of Acute Kidney Injury

This article critiques current, clinical approaches to determining AKI aetiology alongside future areas in which significant developments in patient phenotyping based on pathophysiological principles may occur. In the absence of current alternatives to serum creatinine, current AKI criteria (e.g., those from Kidney Disease Improving Global Outcomes) bring significant advantages in clinical and research environments, including facilitation of efforts to address current variations in the delivery of AKI care. However, their application needs to be accompanied by 2 aspects: an appreciation of the limitations of serum creatinine as a diagnostic test; and an absolute requirement for clinical assessment and diagnostic workup to establish the cause of AKI.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research