Clinical Experience Using Doxycycline and Ursodeoxycholic Acid for the Treatment of Transthyretin Cardiac Amyloidosis

Transthyretin cardiac amyloidosis (ATTR CA) is characterized by extracellular myocardial deposition of amyloid fibrils derived from either the wild-type or mutant forms of the transthyretin protein (TTR).1-3 ATTR CA represents an important cause of progressive heart failure which is now increasingly recognized with improved modern diagnostic strategies.4 Previously, treatment options for ATTR CA were limited to supportive care only, with the possibility of cardiac transplantation for a small number of eligible patients with advanced heart failure.

Source: Journal of Cardiac Failure - January 17, 2019 Category: Cardiology Authors: Erin Karlstedt, Victor Jimenez-Zepeda, Jonathan G. Howlett, James A. White, Nowell M. Fine Source Type: research