Development of a preliminary < i > in vitro < /i > drug screening assay based on a newly established culturing system for pre-adult fifth-stage < i > Onchocerca volvulus < /i > worms

ConclusionThe culture system we have established forO.volvulus young adult worms offers a promising new platform to advance drug discovery against the human filarial parasite,O.volvulus and thus supports the continuous pursuit for effective macrofilaricidal drugs. However, thisin vitro culturing system will have to be further validated for reproducibility before it can be rolled out as a drug screen for decision making in macrofilaricide drug development programs.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research