Optical Coherence Tomography of the Retinal Ganglion Cell Complex in Leber's Hereditary Optic Neuropathy and Dominant Optic Atrophy.

CONCLUSIONS: This article represents the first comparative study of the RGCC between LHON and DOA. Our findings demonstrated significant thickness reductions in pRNFL and macular RGC-IPL in patients with LHON and DOA, with different specific patterns consistent with the general patterns of thinning classically observed. This study suggests the usefulness of the RGCC as a potential in vivo biomarker for assessing disease in patients with LHON and DOA.
PMID: 30649972 [PubMed - as supplied by publisher]

Source: Current Eye Research - January 16, 2019 Category: Opthalmology Authors: Asanad S, Tian JJ, Frousiakis S, Jiang JP, Kogachi K, Felix CM, Darvizeh F, Irvine AG, Ter-Zakarian A, Falavarjani KG, Barboni P, Karanjia R, Sadun AA Tags: Curr Eye Res Source Type: research