Zika and Chikungunya viruses: Diagnostic pitfalls

(German Center for Infection Research) Millions of people have contracted Zika and chikungunya virus infections since the outbreaks that have been striking Latin America since 2013. Particularly Zika-related malformations in newborns warrant reliable diagnostics. DZIF scientists from the Charit é - Universit ä tsmedizin Berlin demonstrate the problems with the currently available diagnostics, particularly for Zika virus detection, and develop combined testing methods that have higher reliability.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Jacobs Robin Ketteler Marcus Dorner Mark Marsh Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made available. Broad-spectrum antivirals are drugs with the potential to inhibit infection by viruses from different groups or families, which may be deployed during outbreaks when specific diagnostics, vaccines or directly acting antivirals are not available. While pathogen-directed approaches are generally effective against ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Chantal B. F. Vogels, Claudia R ückert, Sean M. Cavany, T. Alex Perkins, Gregory D. Ebel, Nathan D. Grubaugh Epidemiological synergy between outbreaks of viruses transmitted byAedes aegypti mosquitoes, such as chikungunya, dengue, and Zika viruses, has resulted in coinfection of humans with multiple viruses. Despite the potential impact on public health, we know only little about the occurrence and consequences of such coinfections. Here, we review the impact of coinfection on clinical disease in humans, discuss the possibility for co-transmission from mosquito to human, and describe a role for modeling transmissi...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
Conclusion: This safe and easy to use multiplex assay allows the discrimination of alphavirus-specific reactivity within a single assay and has potential for epidemiological surveillance. It might also be useful for the development of a pan-alphavirus vaccine.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Non-malarial febrile illness outbreaks were documented in 2007 and 2010 in Gabon. After investigation, these outbreaks were attributed to the chikungunya and dengue viruses (CHIKV and DENV). However, for more than half of the samples analyzed, the causative agent was not identified. Given the geographical and ecological position of Gabon, where there is a great animal and microbial diversity, the circulation of other emerging viruses was suspected in these samples lacking aetiology. A total of 436 undiagnosed samples, collected between 2007 and 2013, and originating from 14 urban, suburban, and rural Gabonese locations wer...
Source: Intervirology - Category: Virology Source Type: research
This report summarizes the lectures held at the meeting and highlights advances in the field.
Source: Antiviral Therapy - Category: Virology Source Type: research
This report summarizes the lectures held at the meeting and highlights advances in the field. PMID: 30597184 [PubMed - as supplied by publisher]
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
ARBOVIRUS INVESTIGATION IN PATIENTS FROM MATO GROSSO DURING ZIKA AND CHIKUNGUNYA VIRUS INTRODUTION IN BRAZIL, 2015-2016. Acta Trop. 2018 Dec 12;: Authors: de Souza Costa MC, Siqueira Maia LM, de Souza VC, Gonzaga AM, de Azevedo VC, Martins LR, Chaves Pavoni JH, Naveca FG, Slhessarenko RD Abstract Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less than five days in Mato Grosso state (MT) du...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Authors: Horstick O, Boyce R, Runge-Ranzinger S Abstract This review discusses biological and chemical methods for dengue vector control, using recently emerging summary evidence, meta-analyses and systematic reviews to conclude on practical public health recommendations for Aedes control, which is increasingly relevant in an era of widespread Chikungunya, yellow feer and Zika outbreaks. The analysis follows an a priori framework of systematic reviews by the authors on vector control methods, distinguishing vector control methods into biological, chemical and environmental methods. Findings of each published system...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
ConclusionsIAM supports implementation of the World Health Organisation Global Vector Control Response (WHO GVCR) and provides a comprehensive framework for health authorities to devise and deliver sustainable, effective, integrated, community-based, locally adapted vector control strategies in order to reduce the burden ofAedes-transmitted arboviruses. The success of IAM requires strong commitment and leadership from governments to maintain proactive disease prevention programs and preparedness for rapid responses to outbreaks.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract The U.S. territory of American Samoa has experienced recent outbreaks of illnesses caused by viruses transmitted by Aedes species mosquitoes, including dengue, chikungunya, and Zika virus. In November 2016, a traveler from the Solomon Islands tested positive for infection with dengue virus type 2 (DENV-2). Additional dengue cases were identified in the subsequent weeks through passive and active surveillance. Suspected dengue cases were tested locally with a dengue rapid diagnostic test (RDT) for DENV nonstructural protein 1 (NS1). Specimens from RDT-positive cases and patients meeting the dengue case def...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
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