A new chlorinated diphenyl ether and a new sesquilignan from the stems of Mappianthus tomentosus

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Shan-Shan Zhu, Gui-Jie Zhang, Hai-Bing Liao, Heng-Shan Wang, Dong LiangAbstractA new chlorinated diphenyl ether, ethyl dichloroasterrate (1), and a new sesquilignan, mappilignan A (2), along with two known diphenyl ethers (3 and 4) and one known sesquilignan (5), were isolated from the stems of Mappianthus tomentosus. The structures of 1−5 were assigned by spectroscopic data analysis and by comparison with literature data. The absolute configuration of 2 was established using experimental and calculated ECD data. Compound 2 displayed inhibition of nitric oxide production in lipopolysaccharide (LPS)-induced BV-2 microglial cells, with IC50 value of 38.87 ± 2.27 μM.Graphical abstract

Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research