National Health Security Strategy 2019-2022

Source: Office of the Assistant Secretary for Preparedness and Response [U.S. Department of Health and Human Services] (HHS ASPR). Published: 2019. This 24-page National Health Security Strategy (NHSS) provides a vision for strengthening the nation ’s ability to prevent, detect, assess, prepare for, mitigate, respond to, and recover from 21st century health security threats. Its objectives are to prepare, mobilize, and coordinate a whole-of-government approach in the event of a public health emergency, disaster, or attack; protect the nation from the health effects of emerging and pandemic infectious diseases and chemical, biological, radiological, and nuclear (CBRN) threats; and leverage the capabilities of the private sector. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news

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Abstract The face of the HIV-1/AIDS pandemic has changed significantly thanks to the development of antiretroviral therapy (ART) regimens. Unfortunately, several HIV-associated comorbidities continuously occur in the clinical population, most notably HIV-associated neurocognitive disorders (HAND). While many molecular and cellular mechanisms have been characterized by describing HAND pathology (specifically neuroinflammatory insults and oxidative stress) in the ART era, compromised adult neurogenesis is emerging as a potential new mechanism. Neurogenesis is a dynamic process that generates new neurons and glial ce...
Source: AIDS Reviews - Category: Infectious Diseases Authors: Tags: AIDS Rev Source Type: research
Authors: Salto-Quintana JN, Rivera-Alfaro G, Sánchez-Ramos EL, Gómez-Gómez A, Noyola DE Abstract Influenza is a leading cause of respiratory tract infections worldwide and there is limited information on the impact of the influenza A(H1N1)pdm virus on mortality after the 2009 pandemic. Using national mortality register data through 1998-2015 in Mexico, influenza-associated mortality was estimated for respiratory, cardiovascular, and all-cause events. The proportion of influenza-associated respiratory and cardiovascular deaths among different age groups were compared. There were 8,853,986 death ...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
Obesity is one of the major pandemics of the 21st century. In 2013 –2014, the prevalence of obesity in the US was>35% among men and 40% among women [1]. The World Health Organization (WHO) reported that 39% of men and 39% of women were overweight, and 11% of men and 15% of women were obese in 2016. Thus, approximately 2 billion adults worldwide were overweight and, among them, more than half a billion were obese [2]. Obesity is a chronic disease adversely affecting the quality of life and is associated with many comorbidities, like hypertension, dyslipidemia, type 2 diabetes (T2DM), cardiovascular disease (CVD), n...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral...
Source: ScienceNOW - Category: Science Authors: Tags: Evolution, Genetics r-articles Source Type: news
Research ArticlesS. INAIDA, Y. SHOBUGAWA, S. MATSUNO, R. SAITO, H. SUZUKI,Epidemiology&Infection,Volume 144 Issue 12, pp 2561-2567Abstract
Source: Epidemiology and Infection - Category: Epidemiology Source Type: research
In this study, we characterized the antiviral properties of the most promising compounds as well as investigated their propensity to induce drug resistance. Our results show that some of the selected compounds possess potent, broad-spectrum anti-influenza activity as they efficiently inhibited the replication of several strains of influenza A and B viruses, including an oseltamivir-resistant clinical isolate, with nanomolar or low-micromolar potency. The most promising compounds specifically inhibited the PA−PB1 binding in vitro and interfered with the influenza A virus polymerase activity in a cellular context, with...
Source: Antiviral Therapy - Category: Virology Source Type: research
[Monitor] Hoima -Communities in Hoima and Kikuube districts where commercially viable oil resources have been discovered are grappling with the HIV/Aids pandemic.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Authors: Henry CJ Abstract We live in a world of paradoxes: one half of the world is overweight or obese with abundant access to food and the other half undernourished due to poor food access. It has been estimated that nearly 36% of children in Asia are stunted. Worldwide, approximately 1 in 4 children under the age of 5 years shows stunted growth, making the number of stunted children to 155 million; 52 million children under 5 years are wasted, of which 17 million are severely wasted. Given the wide-scale nature of global malnutrition and its long-term consequences, why has this scar in our consciousness not bei...
Source: Nestlee Nutrition Institute Workshop Series - Category: Nutrition Tags: Nestle Nutr Inst Workshop Ser Source Type: research
Publication date: June 2019Source: Phytochemistry, Volume 162Author(s): Slavica Matić, Emanuela Noris, Roberta Contin, Daniele Marian, Jeremy R. ThompsonAbstractA single-chain variable antibody fragment (scFv) library tested against the non-structural NSP5 protein of human rotavirus A was screened by a yeast two-hybrid system against three proteins derived from the RNA-dependent RNA polymerase (RdRp) of cucumber mosaic virus (CMV), with the aim of blocking their function and preventing viral infection once expressed in planta. The constructs tested were (i) ‘2a’ consisting of the full-length 2a gene (839 amino...
Source: Phytochemistry - Category: Chemistry Source Type: research
In this study, we characterized the antiviral properties of the most promising compounds as well as investigated their propensity to induce drug resistance. Our results show that some of the selected compounds possess potent, broad-spectrum anti-influenza activity as they efficiently inhibited the replication of several strains of influenza A and B viruses, including an oseltamivir-resistant clinical isolate, with nanomolar or low-micromolar potency. The most promising compounds specifically inhibited the PA-PB1 binding in vitro and interfered with the influenza A virus polymerase activity in a cellular context, without sh...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
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