Resist! TAK1 enables endothelial cells to avoid apoptosis

(Osaka University) TNFα-induced cell death is tightly regulated and resisted in endothelial cells. Here, an Osaka University-led research team used a unique type of mouse, in which TAK1 could be deleted in specific tissues, to show that TAK1 is an essential component in ensuring survival of endothelial cells during inflammation and injury, and that TAK1 could be a novel target for anti-angiogenic therapy in cancer treatment.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news