Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis

Publication date: Available online 16 January 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Vasilios Tzilas, Evangelos Bouros, Ilianna Barbayianni, Thodoris Karampitsakos, Sofia Kourtidou, Maria Ntassiou, Ioanna Ninou, Vassilis Aidinis, Demosthenes Bouros, Argyris TzouvelekisAbstractBackgroundVitamin D (VitD) is a steroid hormone with cytoprotective and anti-inflammatory properties. Epidemiological studies have suggested a link between VitD deficiency and risk of development of chronic lung diseases. Its role in lung fibrosis is largely unknown. The aim of our study was to investigate the role of VitD in experimental and human lung fibrosis.MethodsVitD (25-OH-D3, 2 μg/kg) was orally administered from day 3-day 13 following bleomycin-challenge, in 8–10 weeks-old C57/BL6 mice. Mouse Lung Fibroblasts (MLFs) were pre-treated with VitD (2 μM for 24 h) and then stimulated with TGFB1 (10 ng/ml). Serum samples from 93 patients with IPF and other forms of interstitial lung diseases (ILDs) were prospectively collected for VitD measurement.ResultsVitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels. Pre-treatment with...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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VITAMIN D is an essential nutrient that the body absorbs through direct exposure to sunlight. Lacking the sunshine vitamin can impair vital bodily processes, including those associated with muscle function.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
According to a study published inScientific Reports, vitamin D supplementation may reduce blood sugar and body fat in people who are obese and vitamin D deficient.Medical Dialogues
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
European Journal of Clinical Nutrition, Published online: 20 January 2020; doi:10.1038/s41430-020-0558-yVitamin D deficiency 2.0: an update on the current status worldwide
Source: European Journal of Clinical Nutrition - Category: Nutrition Authors: Source Type: research
VITAMIN D is easier to obtain in warmer months when glorious sunshine lands on our skin. The vital vitamin is needed to keep our bones, teeth and muscles in a healthy way. But what happens in the dark, dreary winter days when there isn ’t enough sunlight to sustain our recommended dosage?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 16 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Feres José Mocayar Marón, León Ferder, Russel J. Reiter, Walter ManuchaAbstractFrom an evolutionary point of view, vitamin D and melatonin appeared very early and share functions related to defense mechanisms. In the current clinical setting, vitamin D is exclusively associated with phosphocalcic metabolism. Meanwhile, melatonin has chronobiological effects and influences the sleep-wake cycle. Scientific evidence, however, has identified new actions of both molecules in differen...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Abstract OBJECTIVE: A recent meta-analysis suggested that the association between vitamin D and risk of hypertension was markedly stronger in women aged
Source: Public Health Nutrition - Category: International Medicine & Public Health Authors: Tags: Public Health Nutr Source Type: research
CONCLUSIONS: Correction of vitamin D deficiency in overweight and obese children by vitamin D3 supplementation with 1000 or 2000 IU/d versus 600 IU/d did not affect measures of arterial endothelial function or stiffness, systemic inflammation, or lipid profile, but resulted in reductions in BP and fasting glucose concentration and in improvements in insulin sensitivity. Optimization of children's vitamin D status may improve their cardiovascular health. This trial was registered at clinicaltrials.gov as NCT01797302. PMID: 31950134 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
A walk of as little 20 minutes in the daylight is enough to provide sufficient levels of vitamin D. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Nutrition Source Type: blogs
Publication date: Available online 14 January 2020Source: Life SciencesAuthor(s): Habib Yaribeygi, Mina Maleki, Thozhukat Sathyapalan, Helia Iranpanah, Hossein M. Orafai, Tannaz Jamialahmadi, Amirhossein SahebkarAbstractDiabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially among younger adults. There is an unmet need to find new therapeutic targets for the management of diabetes. Vitamin D is a promising target in the pathophysiolog...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 15 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Rune Holt, Li Juel Mortensen, Katrine Harpelunde Poulsen, John Erik Nielsen, Hanne Frederiksen, Niels Jørgensen, Anne Jørgensen, Anders Juul, Martin Blomberg JensenAbstractProduction of testosterone is under tight control by human chorion gonadotropin (hCG) during fetal life and luteinizing hormone (LH) in adulthood. Several animal and human studies have linked vitamin D status with sex steroid production although it is not clear whether there exist a direct or indirect involvement in ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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