Autophagy and skeletal muscles in sepsis

This study tests the hypotheses that the locomotor muscles are more prone to sepsis-induced mitochondrial injury, depressed biogenesis and autophagy induction compared with the ventilatory muscles. The authors conclude that locomotor muscles are more prone to sepsis-induced mitochondrial injury, decreased biogenesis and increased autophagy compared with the ventilatory muscles and that autophagy in skeletal muscles during sepsis is regulated in part through the NF κB transcription factor.

Source: Current Awareness Service for Health (CASH) - January 17, 2019 Category: Consumer Health News Source Type: news