Haemochromatosis 'bigger threat than we thought'

Genetic disorder Haemochromatosis can cause liver failure, diabetes and severe arthritis if untreated.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

Related Links:

CONCLUSIONS Apigenin protects renal tubular epithelial cells against high glucose-induced injury through suppression of oxidative stress and inflammation via activation of the Nrf2 pathway. PMID: 31309931 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Liu J, Bhuvanagiri S, Qu X Abstract The aim of the present study was to investigate the effect of Lycopus lucidus Turcz (LT) on diabetic retinopathy (DR) and its underlying mechanisms. SD rats and human retinal microvascular endothelial cells (HRECs) were applied for establishment DR model. HE and TUNEL staining were used to evaluate the pathological changes and apoptosis of retinal ganglion cells. Additionally, retinal vessels were detected by immunofluorescence staining with CD31 and VEGF. The function of BRB was observed using Evans blue. Moreover, the oxidative stress, inflammation and angiogenesis ass...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Publication date: Available online 17 July 2019Source: Neuroscience LettersAuthor(s): Anamaria Falcão Pereira, Lus Mário Silva Pereira, Cristiane Maria Pereira Silva, Bruno Wesley Freitas Alves, Jéssica Sales Barbosa, Francisco Maxwell Martins Pinto, Ana Carolina Pereira, Karla Oliveira Silva, Renata Bessa Pontes, Nylane Maria Nunes Alencar, Roberto César Pereira Lima-Júnior, Mariana Lima ValeAbstractOxaliplatin is a third-generation platinum drug commonly used as the first line treatment of metastatic colorectal cancer. Oxaliplatin-based anticancer regimens course with dose-limiting neur...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 17 July 2019Source: Neuroscience LettersAuthor(s): Alagudurai Krishnamoorthy, Murugan Sevanan, Sugumar Mani, Mangayarkarasi Balu, Sravani Balaji, Ramajayan PAbstractParkinson disease occurs due to the depletion of dopaminergic neurons in brain resulting in decreased dopamine level and abnormal protein aggregation. Chrysin is a flavonoid which possesses pharmacological properties against various diseases like hypertension, diabetes, cancer, etc. According to the recent literatures, it is evidenced that chrysin protects mice against Focal Cerebral Ischemia/Reperfusion Injury. The present st...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 17 July 2019Source: Trends in Food Science &TechnologyAuthor(s): Lijun Sun, Fredrick J. Warren, Michael J. GidleyAbstractBackgroundα-Amylase plays an important role in starch digestion, the main source of exogenous glucose in the human diet. Retarding glucose absorption through delaying digestion of starchy foods by inhibiting α-amylase in the digestive tract has potential as a management and/or therapeutic approach to type II diabetes. Polyphenols have been reported to have inhibitory activity against the enzyme.Scope and approachThis review provides an overview of struct...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 17 July 2019Source: Journal of Molecular BiologyAuthor(s): Peter Spégel, Hindrik MulderAbstractThe islets of Langerhans harbor multiple endocrine cell-types that continuously respond to circulating nutrient levels in order to adjust their secretion of catabolic and anabolic hormones. Stimulus-secretion coupling in these cells is largely of metabolic nature, i.e. metabolism of nutrient fuels yields signals that trigger and amplify secretion of hormones. Hence, metabolism in this micro-organ is in a major way in control of whole-body metabolism. Therefore, insights into islet metabol...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Authors: Singh AK, Talwalkar PG, Ahluwalia A, Modi KD, Saboo B Abstract Hypoglycemia is a key barrier to optimum glycemic control in insulin treated diabetes patients. A national level expert group meeting was held at the 11th national insulin summit to analyze published data from clinical studies and guidelines to evolve consensus recommendations on identification and management of hypoglycemia in insulin-treated diabetes patients. This consensus statement emphasizes consideration of suggestive symptoms or blood glucose levels ≤70 mg/dl and ability to self-treat in identification and classification of hypoglyce...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Kalra S, Sahay R Abstract This brief communication describes evidence which proves the beneficial effects of fenofibrate on the retinal vasculature in type 2 diabetes, acting via both lipid lowering and non-lipid lowering mechanisms. It discusses data from FIELD and other trials to support the use of fenofibrate as a secondary preventive therapy for diabetic retinopathy. These data contrast with the lack of retinal benefit shown in major cardiovascular outcome trials of other blood pressure lowering and glucose lowering agents such as empagliflozin, liraglutide, perindopril + indapamide, and ramipril. ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Patil MB, Ragav ED Abstract Introduction: Type-2 Diabetes is a heterogeneous group of disorders characterized by variable degrees of insulin resistance, impaired insulin secretion, and increased glucose production. Obese diabetic patients have 13.5% more chances of developing diabetic complications compared to non - obese diabetic patients. Vitamin D has found to be deficient in diabetic patient and it's role in insulin regulation. Obese females are more prone to develop diabetic complications and hypovitaminosis-D. Materials and Method: Total of 156 female diabetic patients aged 30 to 60 years who are...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Paul R, Nandi A, Roy D, Ghosh R, Sau TJ, Thakur I, Sarkar R Abstract Rheumatoid arthritis (RA) is a multisystem disease with a variety of manifestations. Vasculitis and myositis are two very rare complications of RA. However, the coexistence of both of these complications in the same patient is extremely rare in medical literature. We here present such a rare association of clinical features in a 36 year old male patient with RA. He had RA for around four years before development of these complications almost simultaneously. The patient was treated with rituximab and oral steroids. The myositis component r...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
More News: Arthritis | Diabetes | Endocrinology | Genetics | Haemochromatosis | Health | Liver | Rheumatology | Urology & Nephrology