BRCA1/BRCA2 mutations in Japanese women with ductal carcinoma in situ

ConclusionDCIS is equally as prevalent in patients who wereBRCA mutation carriers as in high familial ‐risk women who were noncarriers, but occurs at earlier age.BRCA2 carriers have higher incidence in DCIS than that ofBRCA1 carriers, and tend to be higher grade and more frequently ER positive and lower proliferation. Total relatives with BC DX ≥2, age at diagnosis ≤35 years and ER+/HER2+ might be independent predictors forBRCA mutation in Japanese women with DCIS and patients of these risk factors should be recommended to receive genetic counseling andBRCA testing.

Source: Molecular Genetics & Genomic Medicine - January 16, 2019 Category: Genetics & Stem Cells Authors: Yan Liu, Yoshimi Ide, Mayuko Inuzuka, Sakiko Tazawa, Yoko Kanada, Yuki Matsunaga, Takashi Kuwayama, Terumasa Sawada, Sadako Akashi ‐Tanaka, Seigo Nakamura Tags: ORIGINAL ARTICLE Source Type: research