Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of difluorinated C17,C27-fragments

Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03152E, PaperEric Jim Thomas, Paul R Mears, Steven Hoekman, Claire Rye, Fiona Bailey, Dominic Byrne, Patrick A Eyers Bryostatins with modified C17-C27 fragments have not been widely studied. The synthesis of 20,20-difluorinated analogues was therefore investigated. Such substitution would inhibit dehydration involving the C19-hydroxyl group and stabilise the... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - January 16, 2019 Category: Molecular Biology Authors: Eric Jim Thomas Source Type: research