The emergence of nitric oxide in the biosynthesis of bacterial natural products.

The emergence of nitric oxide in the biosynthesis of bacterial natural products. Curr Opin Chem Biol. 2019 Jan 10;49:130-138 Authors: Caranto JD Abstract Nitric oxide (NO) has a broad range of biological utilities including as a biosynthon for bacterial natural products (NPs). The biosyntheses of thaxtomin A and rufomycin require an NO-dependent nitration step where a bacterial NO synthase provides the necessary NO and nitration is catalyzed by a cytochrome P450 homolog. Undiscovered NO-dependent biosynthesis pathways are likely to have similar requirements: a pathway dedicated NO source and a metalloenzyme to catalyze the NO-dependent chemistry. This review discusses the current literature on NO-dependent nitration biosynthesis and relevant enzyme mechanisms. The proposal that NO is important for NN bond containing NPs is also explored, particularly for the formations of nitrosamine and nitramine NPs. PMID: 30640032 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research