Isoniazid bactericidal activity involves electron transport chain perturbation.

This study implicates mycobacterial ETC perturbation through NDHs, SDHs, cytochrome bc1 and F0F1 ATP synthase in INH's bactericidal activity and pinpoints the participation of the cytochrome bd oxidase in protection against this drug under stress conditions. PMID: 30642937 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30642937?dopt=Abstract

Source: Antimicrobial Agents and Chemotherapy - January 14, 2019 Category: Microbiology Authors: Zeng S, Soetaert K, Ravon F, Vandeput M, Bald D, Kauffmann JM, Mathys V, Wattiez R, Fontaine V Tags: Antimicrob Agents Chemother Source Type: research