Comparison of prognosis in centrofacial, panfacial and hairline vitiligo: a prospective cohort study.

Comparison of prognosis in centrofacial, panfacial and hairline vitiligo: a prospective cohort study. J Dermatolog Treat. 2019 Jan 14;:1-5 Authors: Zhang L, Zhang C, Xiang L PMID: 30640572 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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We present a 48-year-old woman affected by metastatic uveal melanoma treated with nivolumab (3 mg/kg every 2 weeks). The patient had no previous history of autoimmune disease or dermatologic conditions. At the fourth month of treatment, on cutaneous examination, she presented multiple whitish vitiligo-like patches on the trunk, axillae, hands and face. Diagnosis of melanoma-associated leukoderma vitiliginous reaction was made. Over the following months, the melanoma-associated leukoderma lesions slowly progressed with cigarette paper-like appearance and indurated texture. A skin biopsy leaded the diagnosis of extragenital ...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
ConclusionsTopical tacrolimus ointment 0.03% or pimecrolimus cream 1% have efficacy for vitiligo in infants, which serves to achieve an appropriate level of safety and tolerability during the 6-month period of applications. Thus, TCIs proved to be a therapeutic option for vitiligo in infants under 2  years of age.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
ConclusionsImmunosuppression resulted in clinical remission of each irAE, highlighting the importance of vigilance for autoimmune complications in patients treated with checkpoint inhibition, even after immunotherapy cessation.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 4 September 2019Source: Journal of Molecular LiquidsAuthor(s): Wanessa de Souza Cardoso Quintão, Thuany Alencar-Silva, Maria de Fátima Borin, Kennia Rocha Rezende, Lorena C. Albernaz, Marcilio Cunha-Filho, Tais Gratieri, Juliana Lott de Carvalho, Livia C.L. Sá-Barreto, Guilherme Martins GelfusoAbstractThe purpose of the study reported here was to develop and characterize microemulsions incorporating two ethanolic extracts of Brosimum gaudichaudii with different origins for topical application to treat the pigmentation disorder vitiligo. After plant extracts were obtai...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
MicroRNA‑155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo. Mol Med Rep. 2019 Aug 23;: Authors: Lv M, Li Z, Liu J, Lin F, Zhang Q, Li Z, Wang Y, Wang K, Xu Y Abstract It has been reported that loss and degradation of epidermal melanocytes is closely associated with the pathogenesis of vitiligo. In addition, CD8+ T and regulatory T (Treg) cells serve an important role during these two processes. MicroRNA‑155 (miR‑155) is known to contribute to the pathogenesis of vitiligo; however, the mechanism by which miR‑155 regulates the development of vitil...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Liu W, Ma DL PMID: 31481426 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
In conclusion, miR-9 was suppressed by IL-10 and inhibited migration of PIG1 cells to HaCaT cells during UVB-mediated vitiligo repigmentation. PMID: 31499059 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research
This article presents the case of a 68-year-old female patient who reported bilateral progressive visual loss over 4 weeks. The patient had a known metastatic malignant cutaneous melanoma, which was treated with the immune checkpoint inhibitors nivolumab and ipilimumab. The ophthalmological examination revealed a bilateral anterior chamber flare with endothelial precipitates as well as choroidal folds, an orange-red discoloration of the retina and a serous retinal/choroidal detachment in the left eye. In the course of time the patient developed poliosis and vitiligo. Systemic and local steroid treatment...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Immune checkpoint inhibitors (ICIs), which target CTLA-4 or PD-(L)1 molecules, have shown impressive therapeutic results. Durable responses, however, are only observed in a segment of the patient population and must be offset against severe off-target immune toxicity and high costs. This calls for biomarkers that predict response during ICI treatment. Although many candidate biomarkers exist, as yet, there has been no systematic overview of biomarkers predictive during. Here, we provide a systematic review of the current literature of ICI treatment to establish an overview of candidate predictive biomarkers during ICI trea...
Source: Melanoma Research - Category: Cancer & Oncology Tags: Review Article Source Type: research
GPNMB is a highly glycosylated type I transmembrane protein, which is known to be expressed in many cell types with multiple functions including cell adhesion, stress protection, and stem cell maintenance. In the skin, melanocyte GPNMB is suggested to mediate pigmentation through melanosome formation, but details of its expression and function in epidermal keratinocytes are not well characterized. We previously confirmed the predominant expression of GPNMB at a lower calcium condition in cultured normal human epidermal keratinocytes (NHEK).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Photobiology and Pigmentation Source Type: research
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