Acute Administration of Nigella sativa Showed Anxiolytic and Anti- Depression Effects in Rats

Objective: Nigella sativa (NS) has been shown to have some effects on the central nervous system. In the present work, anxiolytic and anti- depression effects of an acute administration of hydro- alcoholic extract of NS was investigated in rats. Materials and Methods: The rats were grouped and treated 30 min before conducting the behavioral tests: (1) saline as a control group, (2-4) three groups including NS 100, NS 200 and NS 400 treated by three doses (100, 200 and 400 mg/ kg) of NS. The animals were examined using Forced Swim Test (FST), Open-Field (OFT) and Elevated Plus Maze (EPM) tests. Results: NS extract improved the time spent, crossing number and traveled distance in the central zone in OFT compared to the control group (p
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research