Anti-inflammatory and antioxidant jasmonates and flavonoids from lychee seeds

In this study, bioactive phytochemical study of the seeds of lychee led to the isolation and identification of four methyl jasmonate analogs (1–4), one lignanoside (5), together with fifteen flavonoids (6–20). Their chemical structures were established on the basis of spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR spectra. The anti-inflammatory and antioxidant activities were evaluated for the isolated compounds. Compounds 2 and 3 exhibited notable inhibition on NO production induced by lipopolysaccharides (LPS) in macrophages cell line RAW 264.7. Compound 5 and some flavonoids revealed potent antioxidant capacities. The results disclosed that the methyl jasmonates in lychee seeds may be partially responsible for anti-inflammatory activity of lychee and could be served as anti-inflammatory agent in functional food.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research