Isolation, solid-state structure determination, in silico and in vitro anticancer evaluation of an indole amino acid alkaloid L-Abrine †.

CONCLUSION: The solid-state zwitterion structure of the indole-containing alkaloid (α-methylamino-β-indolepropionic acid, L-abrine) has been confirmed for the first time by X-ray crystallography. Highly promising in silico and in vitro results indicate that L-abrine may find its space in future anticancer drug discovery research.
PMID: 30636612 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - January 10, 2019 Category: Cancer & Oncology Authors: Laskar S, Espino O, Bandyopadhyay D Tags: Curr Cancer Drug Targets Source Type: research