Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy

ConclusionThe present investigation showed that ungeremine is a promising cytotoxic compoundthat could be further explored in the future to develop new anticancer drugs to fight sensitive and resistant phenotypes.Graphical abstractUngeremine had cytotoxic effects on a panel of 9 cancer cell lines including dug-sensitive and multidrug-resistant phenotypes, with IC50 values below 75.24 µM. This compound induced ferroptosis, necroptosis, autophagy in CCRF-CEM leukemia cells, as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production.
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research