The Association Between Psychotropic Drug Use and Fertility Problems Among Male Subjects

This article summarizes the data with regard to the effects of 6 widely used psychotropic drugs—lithium, valproate, haloperidol, olanzapine, imipramine, and fluoxetine—on sexual function and sperm parameters in male subjects. In general, the reviewed data suggest that these medications can be associated with sexual function problems and negative effects on sperm parameters among male subjects. It is important to note that most of the data are based on preclinical studies and nonrandomized clinical trials with relatively small sample sizes, so that it is not possible to draw unequivocal conclusions with regard to the clinical relevance of the findings. Prospective, randomized clinical trials are necessary to elucidate the effects of psychotropic drugs on men’s sperm parameters and fertility indices per se.
Source: Journal of Psychiatric Practice - Category: Psychiatry Tags: ARTICLES Source Type: research