Activation of ENaC by AVP Contributes to Urinary Concentrating Mechanism and Dilution of Plasma.

Activation of ENaC by AVP Contributes to Urinary Concentrating Mechanism and Dilution of Plasma. Am J Physiol Renal Physiol. 2014 Nov 12;:ajprenal.00246.2014 Authors: Mironova E, Chen Y, Pao AC, Roos KP, Kohan DE, Bugaj V, Stockand JD Abstract Vasopressin (AVP) activates the epithelial Na+ channel (ENaC). The physiological significance of this activation is unknown. The current studies test if activation of ENaC contributes to AVP-sensitive urinary concentration. Consumption of a 3% NaCl solution induced hypernatremia and plasma hypertonicity in mice. Plasma [AVP] and urine osmolality increased in hypernatremic mice in an attempt to compensate for increases in plasma tonicity. ENaC activity was elevated in mice consuming 3% NaCl solution compared to mice consuming a diet enriched in Na+ with ad libitum tap water. The latter diet does not cause hypernatremia. To determine whether the increase in ENaC activity in mice consuming 3% NaCl solution served to compensate for hypernatremia, mice were treated with the ENaC inhibitor benzamil. Co-administration of benzamil with 3% NaCl solution decreased urinary osmolality and increased urine flow so that urinary Na+ excretion increased with no effect on urinary [Na+]. This decrease in urinary concentration further increased plasma [Na+], osmolality, and [AVP] in these already hypernatremic mice. Benzamil similarly compromised urinary concentration in water deprived mice and in mice treated with desmopressin. These...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
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Source: Polymer Testing - Category: Chemistry Source Type: research
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Source: Materials Letters - Category: Materials Science Source Type: research
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Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
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Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
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Source: MethodsX - Category: Science Source Type: research
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