Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification [Biochemistry]

Scaffold proteins tether and orient components of a signaling cascade to facilitate signaling. Although much is known about how scaffolds colocalize signaling proteins, it is unclear whether scaffolds promote signal amplification. Here, we used arrestin-3, a scaffold of the ASK1-MKK4/7-JNK3 cascade, as a model to understand signal amplification by a...

Source: Proceedings of the National Academy of Sciences - January 15, 2019 Category: Science Authors: Nicole A. Perry, Tamer S. Kaoud, Oscar O. Ortega, Ali I. Kaya, David J. Marcus, John M. Pleinis, Sandra Berndt, Qiuyan Chen, Xuanzhi Zhan, Kevin N. Dalby, Carlos F. Lopez, T. M. Iverson, Vsevolod V. Gurevich Tags: Biological Sciences Source Type: research