Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters [Biochemistry]

A major challenge in drug development is the optimization of intestinal absorption and cellular uptake. A successful strategy has been to develop prodrug molecules, which hijack solute carrier (SLC) transporters for active transport into the body. The proton-coupled oligopeptide transporters, PepT1 and PepT2, have been successfully targeted using this approach....

Source: Proceedings of the National Academy of Sciences - January 15, 2019 Category: Science Authors: Gurdeep S. Minhas, Simon Newstead Tags: Biological Sciences Source Type: research