Liver transplant 'game changing' treatment approved
It's hoped perfusion machines that "warm livers" will increase the number of viable donated organs.
This study aimed to investigate the effects of various perfusion temperatures on lung graft preservation during ex vivo lung perfusion (EVLP).
The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been propos...
Conditions: Myocardial Perfusion Imaging; Liver Failure Intervention: Procedure: Myocardial perfusion imaging Sponsor: University Hospital Birmingham NHS Foundation Trust Active, not recruiting
Authors: Kim JS, Kim KW, Choi SH, Jeong SY, Kwon JH, Song GW, Lee SG Abstract OBJECTIVE: To investigate whether diagnostic performance of contrast-enhanced ultrasound (CEUS) could be improved with modified criteria to diagnose significant hepatic artery occlusion (HAO) and to determine the role of CEUS in patients with a tardus-parvus hepatic artery (HA) pattern on Doppler US. MATERIALS AND METHODS: Among 2679 adult liver transplantations performed over 7 years, HAO was suspected in 288 recipients, based on Doppler ultrasound. Among them, 130 patients underwent CEUS. After excluding two technical failures, 128 ...
No abstract available
Splenic arterial steal syndrome (SASS) is preferential splenic arterial flow with hepatic arterial hypo-perfusion seen on angiography without hepatic arterial anatomical abnormality. The study compares liver Doppler findings before and after splenic embolization
ConclusionsThis study demonstrates major differences in approach to DCD ‐LT. To assure both donors and recipients a consistent standard of care, a consensus meeting on DCD‐LT is highly recommended.This article is protected by copyright. All rights reserved.
CONCLUSION: Exogenous VEGF-C protects liver graft from IRI by regulating the inflammatory response and modifying polarization of KCs. PMID: 30771456 [PubMed - as supplied by publisher]
Conclusions The outcome of DCD organs can be improved by the addition of mcc950 to the perfusate of the HMP system and intravenous injection of mcc950 after transplantation.
CONCLUSIONS: Cow placentomes will allow therapeutic development with disease models in small animals. This will also advance drug or toxicology studies. Portasystemic interposition of engineered liver will be particularly suitable for treating hepatic insufficiencies (metabolic, secretory or detoxification needs), including for children or smaller adults. PMID: 30678914 [PubMed - in process]