Liver transplant 'game changing' treatment approved

It's hoped perfusion machines that "warm livers" will increase the number of viable donated organs.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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This study aimed to investigate the effects of various perfusion temperatures on lung graft preservation during ex vivo lung perfusion (EVLP).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 583 Source Type: research
The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been propos...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Study protocol Source Type: research
Conditions:   Myocardial Perfusion Imaging;   Liver Failure Intervention:   Procedure: Myocardial perfusion imaging Sponsor:   University Hospital Birmingham NHS Foundation Trust Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Kim JS, Kim KW, Choi SH, Jeong SY, Kwon JH, Song GW, Lee SG Abstract OBJECTIVE: To investigate whether diagnostic performance of contrast-enhanced ultrasound (CEUS) could be improved with modified criteria to diagnose significant hepatic artery occlusion (HAO) and to determine the role of CEUS in patients with a tardus-parvus hepatic artery (HA) pattern on Doppler US. MATERIALS AND METHODS: Among 2679 adult liver transplantations performed over 7 years, HAO was suspected in 288 recipients, based on Doppler ultrasound. Among them, 130 patients underwent CEUS. After excluding two technical failures, 128 ...
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: In Brief Source Type: research
Splenic arterial steal syndrome (SASS) is preferential splenic arterial flow with hepatic arterial hypo-perfusion seen on angiography without hepatic arterial anatomical abnormality. The study compares liver Doppler findings before and after splenic embolization
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 26: Something New, Something Blue (Transplant and Splenic Interventions) Source Type: research
ConclusionsThis study demonstrates major differences in approach to DCD ‐LT. To assure both donors and recipients a consistent standard of care, a consensus meeting on DCD‐LT is highly recommended.This article is protected by copyright. All rights reserved.
Source: Journal of Hepato-Biliary-Pancreatic Sciences - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
CONCLUSION: Exogenous VEGF-C protects liver graft from IRI by regulating the inflammatory response and modifying polarization of KCs. PMID: 30771456 [PubMed - as supplied by publisher]
Source: Transplant Immunology - Category: Transplant Surgery Authors: Tags: Transpl Immunol Source Type: research
Conclusions The outcome of DCD organs can be improved by the addition of mcc950 to the perfusate of the HMP system and intravenous injection of mcc950 after transplantation.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—Liver Source Type: research
CONCLUSIONS: Cow placentomes will allow therapeutic development with disease models in small animals. This will also advance drug or toxicology studies. Portasystemic interposition of engineered liver will be particularly suitable for treating hepatic insufficiencies (metabolic, secretory or detoxification needs), including for children or smaller adults. PMID: 30678914 [PubMed - in process]
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
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