Medical detection dogs help diabetes patients regulate insulin levels

New research by the University of Bristol in collaboration with Medical Detection Dogs has found that the best trained alert dogs have the potential to vastly improve the quality of life of people living with Type 1 diabetes.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Veterinary School; Press Release Source Type: news

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Authors: Xie Z, Chang C, Huang G, Zhou Z Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction between genetic alterations and environmental factors. More than 60 susceptible genes or loci of T1D have been identified. Among them, HLA regions are reported to contribute about 50% of genetic susceptibility in Caucasians. There are many environmental factors involved in the pathogenesis of T1D. Environmental factors may change the expression of genes through epigenetic mechanisms, thus inducing individuals with susceptible genes to develop T1D; however, the underlying mechanisms remain ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
AbstractDiabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound catabolism with increased gluconeogenesis, glycogenolysis, lipolysis, and muscle proteolysis causing hyperglycemia and osmotic diuresis. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of ‘ketone bodies’ into the circulation, which dissociate to release hydrogen ions and cause an overwhelming acidosis. Dehydration, hyperglycemia, and ketoacidosis are the hallmarks of this condition. Treatment is effective repletion of ...
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
Purpose: To analyze the evolution of macular vessel density (VD) over 1 year, during early worsening of diabetic retinopathy, in patients with uncontrolled Type 1 diabetes (T1D). Methods: Retrospective study of 12 eyes of 9 patients with T1D with early worsening of diabetic retinopathy imaged with optical coherence tomography angiography. The following data were collected at the time of pan retinal photocoagulation initiation and after 6 and 12 months: vessel density within three retinal plexuses—superficial vascular plexus, intermediate capillary plexus, and deep capillary plexus; foveal avascular zone area, ac...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
DiabetesMine delves into the misinformation about type 1 diabetes by actress Halle Berry.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
CONCLUSIONS: The present study suggests that young, uncomplicated patients with type 1 diabetes have a higher estimated peak systolic pulmonary artery pressure. Further studies are needed to define the mechanisms underlying this alteration and its clinical consequences. PMID: 32432766 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstrated that humans with DKD have significantly reduced levels of mitochondrion-derived metabolites in their urine. Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal su...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Metabolism Source Type: research
In this volume of The Journal, Kao et al report a retrospective cohort of youth with type 1 diabetes (T1D) with 11 years of data (from 2002-2012) on incidence trends of diabetic ketoacidosis (DKA) in children and adolescents with T1D in British Columbia, Canada. The authors found that among 2615 incident cases of T1D, 32.4% presented in DKA. Rates of DKA at diagnosis remained stable over 11 years with a range of 24.1 to 37.3 per 100 person-years. Similarly, rates of DKA in youth with diagnosed T1D were stable with a range of 4.9 to 7.7 per 100 person-years.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
To estimate the 11-year incidence trend of diabetic ketoacidosis (DKA) at and after the diagnosis of type 1 diabetes.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Article Source Type: research
Publication date: June 2020Source: The Lancet Diabetes &Endocrinology, Volume 8, Issue 6Author(s): Ronnie Aronson, Aihua Li, Ruth E Brown, Sarah McGaugh, Michael C Riddell
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
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