Alteplase and DNase for the treatment of pleural empyema in rats

ConclusionsAlteplase, DNase and alteplase + DNase changed significantly physical and chemical properties of experimental empyema at fibrinopurulent phase: alteplase reduced molecular size larger than 135 nm and DNase reduced viscosity.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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In this study, we compared the accuracy of B-PFG measurement to standard in-lab measurement (Lab-PFG). Methods: Patients undergoing thoracentesis or thoracostomy were enrolled. PFG was measured at the bedside with a finger stick blood glucometer (ACCU-CHEK® Inform II, Roche) and in the laboratory. Two consecutive measurements were taken using the glucometer, and their mean was compared to the glucose concentration measured in the laboratory. Pearson correlation coefficient and Bland-Altman Plot analysis were used to compare the two measurements. Results: Sixty patients were included. Mean age was 64.1 years. Fo...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
We report a case of UT associated with trauma.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Conclusion: There was variation in the practice patterns of attending physicians in performing thoracentesis in patients with elevated bleeding risk. Further data and guidelines regarding the safety of thoracentesis in these patients are needed.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
ConclusionFollowing ultrasound-guided thoracentesis, the incidence of pneumothorax requiring chest tube decompression is only 1 in 170. Of the 1 in 30 patients who develop a pneumothorax, only 1 in 6 require a chest tube. This information can inform procedural consent discussions as well as future guidelines about the necessity of routine postprocedural chest radiography.
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 2 December 2019Source: Medical Journal Armed Forces IndiaAuthor(s): Rajat Prabhakar, M.H.A. KhanAbstractReexpansion pulmonary edema is a rare complication of thoracocentesis with mortality rates as high as 20%. It presents with tachycardia, hypotension, and hypoxemia within hours after thoracocentesis. The exact pathophysiology is not known. The risk factors for the same should be carefully assessed and considered before chest tube drainage. The treatment is supportive. A case of ipsilateral reexpansion pulmonary edema after chest tube drainage of spontaneous pneumothorax is described and...
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
Conclusion: Our study confirms that the incidence of malignancy in idiopathic pleuritis after VATS is low. Nearly all incident cases of malignancy were diagnosed within 12 months from VATS. Our data suggest that follow-up of idiopathic pleuritis could be limited to 1 year, however, the optimal follow-up strategy remains to be investigated. No survival disadvantage was observed, supporting the grave prognosis of pleural malignancy.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pleural and mediastinal malignancies Source Type: research
Fungal infections have increased in the last few decades as a result of the use of broad-spectrum antibiotics and the growing number of immunocompromised patients (pts), which have led to changes in the saprophytic microorganisms usually isolated. Fungal empyema (FE) is still a rare entity, with a mortality rate of 70%. Retrospective analysis of fungal pleural effusions diagnosed in our hospital between 2015 and 2018. Aseptic sampling of pleural fluid was performed by thoracentesis, chest drainage (CT) or video-assisted thoracoscopic surgery (VATS). Seventeen fungal isolates were obtained from 15 pts (12 males, mean age 60...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Conclusions: The publication has not improved our level of compliance. To improve these results proactive measures should be established such as homogenizing and simplifying IC.Table 1.Indicators20172018Statistic analysisTIC: YES/n (%)125/146 (86%)107/139 (77%)p: 0.061TTNBIC: YES/n (%)18/20 (90%)14/19 (74%)p: 0.235
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Ethics and economics Source Type: research
Introduction: Pleural effusion is considered the most common presentation of pleural diseases; around 50% of cases of pleural effusion remain undiagnosed following thoracentesis.Purpose: To compare between the diagnostic accuracy, safety and complications of medical thoracoscopic (MT) versus CT guided (CTG) tru-cut pleural biopsy.Patients and Methods: The patients with unexplained exudative pleural effusion were classified into two groups for either MT or CTG tru-cut pleural biopsy. The pleural biopsies obtained during both procedures were sent for mycobacterial culture and histopathology.Results: Complications of MT were ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pleural and mediastinal malignancies Source Type: research
Conclusion: US guided biopsy of peripheral lung, pleural, soft tissue or musculoskeletal lesions can be performed safely with high diagnostic yield by respiratory physicians.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
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