Muscle stem cells can drive cancer that arises in Duchenne muscular dystrophy

People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells' continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

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Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
Publication date: Available online 30 July 2020Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Salem El Sayed Deraz, Sameh Abd Allah Abd El Naby, Asmaa Abdel Sameea Mahmoud
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
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We report that even before tumor formation, MuSCs exhibit increased self-renewal and an expression signature associated with RMSs. These cells can form tumorspheres in vitro and give rise to RMSs in vivo. Finally, we show that the inflammatory genes Ccl11 and Rgs5 are involved in RMS growth. Together, our results show that DMD severity drives MuSC-mediated RMS development.Graphical Abstract
Source: Cell Reports - Category: Cytology Source Type: research
Dystrophin inactivation, responsible for Duchenne muscular dystrophy (DMD), is recently implicated as an anti-tumor suppressor factor in cancers with myogenic characteristics. Rhabdomyosarcoma (RMS), a mesodermal cancer, shows myogenic features and occurs at a higher frequency in mdx mouse, a DMD model mouse. In humans, as the clinical management of DMD advances to increase the life expectancy of patients, a subsequent issue is anticipated to be that of addressing other complications such as RMS.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
The DMD gene encoding dystrophin is mutated in Duchenne muscular dystrophy, a fatal progressive muscle wasting disease. DMD has also been shown to act as a tumor suppressor gene. Rhabdomyosarcoma (RMS) is a mesod...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Source Type: research
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