Resistin: a reappraisal

Publication date: Available online 14 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): E. Acquarone, F. Monacelli, R. Borghi, A. Nencioni, P. OdettiAbstractFrom a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging.Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases.Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research