Tails of a Super Histone

Publication date: 14 January 2019Source: Cancer Cell, Volume 35, Issue 1Author(s): Patrick Sin-Chan, Iqra Mumal, Annie HuangDiffuse intrinsic brain stem gliomas (DIPGs) with characteristic K27M mutation of H3.3 are lethal and poorly understood childhood cancers. In this issue of Cancer Cell, Larson et al. exploit a unique murine DIPG model with inducible, endogenous K27M expression to reveal insights into mechanisms of K27M-mediated transformation in DIPG.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research