Noblesse oblige: critical issues at the highest level of clinical evidence

Systematic reviews and meta-analyses are considered to represent the highest level of clinical evidence, especially when it comes to the assessment of all available research data on the efficacy and effectiveness of interventions. This of course requires that the evaluated research is relevant for the question under study, and that the reviews and meta-analyses meet essential criteria of methodological quality, reproducibility and objectivity. Also, independence and impartiality are crucial. Preferably avoidance of –but at least appropriately and transparently managing–any potential conflicts of interest so that these cannot influence the results, must be guaranteed.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Tags: Editorial Source Type: research
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