Comparability of treatment arms does not prevent  correlated trial results

In a simulation study [1], we identified possible dependence between trial results when conducting multiple trials within a cohort multiple randomized controlled trial (cmRCT) setting [2]. In their letter, Verkooijen et  al. [3] argue that contrary to our results, there is “no concern for dependency” as long as eligible patients for any given new trial are randomly selected into either of its arms. We disagree with this assertion.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Tags: Letter to the Editor Source Type: research
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