A Surgeon Reflects On Death, Life And The 'Incredible Gift' Of Organ Transplant
Joshua Mezrich has performed hundreds of kidney, liver and pancreas transplants. He shares stories from the operating room in his book, When Death Becomes Life.(Image credit: shapecharge/shapecharge/Getty Images)
Congenital hepatic fibrosis (CHF) is a rare genetic liver disease (1/20,000 births) characterized by ductal plate malformation during bile duct development and progressive hepatic fibrosis, and is often associated with autosomal recessive polycystic kidney disease. Liver transplantation is necessary for the treatment of progressive CHF patients with a severe phenotype. There are several pathological evidences to indicate that the mechanism of fibrosis in CHF is quite different from liver cirrhosis due to chronic hepatitis: hepatic fibrosis in CHF patients lacks necroinflammatory changes of hepatocytes and the activation...
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Publication date: Available online 15 March 2019Source: The Annals of Thoracic SurgeryAuthor(s): Alan S. Chou, Andreas Habertheuer, Amanda L. Chin, Ibrahim Sultan, Prashanth VallabhajosyulaAbstractBackgroundPrior single-center studies suggest kidney and liver allografts are immunoprotective toward transplanted hearts. The broader effects of simultaneous transplantation of kidney or liver on protection from rejection are unclear.MethodsThe United Network for Organ Sharing database for heart transplantation was queried from 1987 to 2015 and stratified into patients undergoing heart-liver (HLT; n=192), heart-kidney (HKT; n=11...
This study aimed to investigate the effects of various perfusion temperatures on lung graft preservation during ex vivo lung perfusion (EVLP).
Cervical cancer is the most common gynecological cancer worlwide. Squamous intraepithelial lesions (SIL) are known precursors for carcinoma of uterine c èrvix and associated to infection by human papillomavirus (HPV). Several studies have shown an increased risk of malignant anogenital lesions in recipients of kidney and liver transplants compared to the general population, but there is less information in heart transplanted recipient
Right heart failure following left ventricular assist device implantation is one of the major challenges in patients suffering from advanced heart failure. There is still no ideal right-sided support system available. Here we describe the implantation of a stent valve at the inferior cavoatrial junction to protect liver and kidney during right heart failure.
The impact of opioid use in lung transplant (LTx) candidates on post-transplant outcomes is unknown. Previous studies on opioid therapy in kidney and liver transplant candidates have suggested increased risk of graft failure or death. We sought to test the association between pre-transplant opioid use in LTx candidates and overall retransplant-free survival.
The Model of End-Stage Liver Disease (MELD) score incorporates measures of kidney and liver dysfunction. MELD score has been shown to predict mortality in patients with advanced heart failure or cardiogenic shock (CS). Prior small single-center studies have shown that MELD score predicts mortality in patients supported with Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). The Purpose of our was to reassess the role of MELD score predicting Mortality After (VA-ECMO).
This report investigates the effect of renal diagnosis on survival in patients undergoing simultaneous liver-kidney transplant (SLK). This is a timely and very controversial issue and one that will likely continue to increase.
Abstract OBJECTIVES: Acute kidney injury after pediatric liver transplant is associated with increased morbidity and mortality. Here, we evaluated children with acute kidney injury early posttransplant using KDIGO criteria to determine incidence, risk factors, and clinical outcomes. MATERIALS AND METHODS: In this retrospective cohort study, medical records of all patients