Frailty and Outcomes After Liver Transplantation

AbstractPurpose of ReviewFrailty is an emerging concept in liver transplantation. We reviewed the literature for the tests of frailty which have been validated to predict outcomes in patients with cirrhosis evaluated for liver transplantation.Recent FindingsSeveral tools have been developed to further stratify risk of adverse events independent of liver disease severity. These include tests of disability such as activities of daily living and the Karnofsky Performance Score, as well as tests of physical frailty, such as the Liver Frailty Index (handgrip, chair stands, and balance).SummaryIncreasingly, the frailty assessment is seen as a critical component of the liver transplant evaluation. Further research is needed to clarify the optimal timing of testing and the implications of longitudinal change.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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CONCLUSION: Chronic viral hepatitis and liver cirrhosis are responsible for a significant burden in Brazil, affecting mainly men and individuals still in their productive years. Most burden is related to non-viral causes of cirrhosis, with a major contribution of alcohol. PMID: 31171330 [PubMed]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Guangwen Luo1†, Bailiang Li1†, Cailu Yang2†, Yutang Wang1, Xin Bian1, Wan Li1, Fei Liu1 and Guicheng Huo1* 1Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, China 2Department of Ultrasound, Maternal and Child Health Hospital of Dapeng New District, Shenzhen, China Modulating gut microbiota to promote host health is well recognized. Therefore, people consume dietary products containing traditional probiotics in wishing to improve their health, and they need more research-based advices on how to select products with sui...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
(Natural News) Liver diseases — including cirrhosis — is a leading cause of death and disability today. One way to protect your liver naturally is to take chicory (Cichorium intybus L.), a flowering plant that belongs to the dandelion family, which has been found to possess hepatoprotective properties. In a study published in the Journal of...
Source: - Category: Consumer Health News Source Type: news
Aspirin is best known as an over-the-counter painkiller. But acetylsalicylic acid, as it’s called chemically, has many other health benefits, as well as side effects, in the body that have only become clear in recent years. Here’s what the latest science says about the health benefits and side effects of aspirin, as well as which conditions it may treat and those it doesn’t appear to improve. (If you are taking aspirin for any reason other than for periodic pain relief, it’s best to consult with your doctor to confirm whether the benefits outweigh the risks in your particular case.) How aspirin affe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Drugs healthytime Source Type: news
Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due to complications of cirrhosis and 1million due to viral hepatitis and hepatocellular carcinoma. Cirrhosis is currently the 11th most common cause of death globally and liver cancer is the 16th leading cause of death; combined, they account for 3.5% of all deaths worldwide. Cirrhosis is within the top 20 causes of disability-adjusted life years and years of life lost, accounting for 1.6% and 2.1% of the worldwide burden.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Seminar Source Type: research
Discussion around this is definitely part of the public discourse now but this is going to turn slowly like an ocean liner as incentives become more aligned.“The reimbursement of volume-based agreements is such a complex calculation to unwind, and people acknowledge that it is sensible but a hard thing to do. It takes a lot to move people off tried-and-true, low-risk ways of measuring the performance of a drug.Related Content: Rid Yourself Of Dirty DataTalking The Same LanguageNavigating the ChaosSeeking the Holy Grail of RWEThe Naked Truth About Outcomes-Based PricingPrimary Event: Value Summit USA 2018Pr ...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Excessive and prolonged alcohol intake is a major cause of advanced liver disease and a major driver of liver-related hospitalisations worldwide.1 In Europe, alcohol-related liver disease (ALD) is the main cause of disability-adjusted life years among adults with alcohol abuse. ALD comprises a broad spectrum ranging from asymptomatic stages to cirrhosis, as well as alcoholic hepatitis and hepatocellular carcinoma (HCC).2 Unfortunately, most patients are identified at late stages, when mortality is very high despite drinking cessation.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research
In this study, we estimated the age-standardized prevalence, mortality, and disability adjusted life years (DALY) rates of GI and liver diseases in India from 1990 to 2016 using data from the Global Burden of Disease (GBD) Study, which systematically reviews literature and reports for international disease burden trends. Despite a decrease in the overall burden from GI infectious disorders since 1990, they still accounted for the majority of DALYs in 2016. Among noncommunicable disorders (NCDs), there were increases in the prevalence and mortality rates for pancreatitis, liver cancer, paralytic ileus and intestinal obstruc...
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Abstract Obesity and metabolic syndrome are considered as responsible for a condition known as the non-alcoholic fatty liver disease that goes from simple accumulation of triglycerides to hepatic inflammation and may progress to cirrhosis. Patients with obesity also have an increased risk of primary liver malignancies and increased body mass index is a predictor of decompensation of liver cirrhosis. Sarcopenic obesity confers a risk of physical impairment and disability that is significantly higher than the risk induced by each of the two conditions alone as it has been shown to be an independent risk factor for c...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
In accordance with the American College of Sports Medicine (ACSM) guidelines for the management of persons with chronic diseases and disabilities[1 –5], exercise training is a key recommendation for all patients with chronic disease. The American Association for the Study of Liver Diseases in its online teaching resource recommends personalized exercise interventions for patients with cirrhosis[6]. The American Society for Transplantation has recommended a robust clinical research agenda for exercise interventions in patients in need of solid organ transplantation[7].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Review Source Type: research
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