Investigation of the relationships between knee osteoarthritis and obesity via untargeted metabolomics analysis

ConclusionAcid concentration and oxidative stress agents were high in inflammation group and their levels were much higher in obesity. It is claimed that obesity cause oxidative stress and acidosis in arthritis patients. Valine was found to be the only BCAA molecule whose concentration has significantly different in KOA patients. The relation between KOA and obesity was firstly investigated with metabolomics method.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research