Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD

We evaluated the relationships between hyperpolarized3He ventilation defect percent (VDP) and respiratory system resistance, reactance andAX oscillometry measurements in 175 participants.R5 ‐19 andX5 demonstrated different relationships with VDP in patients with different disease phenotypes, whereasAX was weakly related to VDP in all subgroups with airflow obstruction. Our results demonstrated thatAX is sensitive to obstruction but not specific to the type of obstruction, and that the different relationships for MRI VDP withR5 ‐19 andX5 may reflect airway and parenchymal disease ‐specific biomechanical abnormalities that lead to ventilation defects. AbstractDeveloped over six decades ago, pulmonary oscillometry has re ‐emerged as a noninvasive and effort‐independent method for evaluating respiratory‐system impedance in patients with obstructive lung disease. Here, we evaluated the relationships between hyperpolarized3He ventilation ‐defect‐percent (VDP) and respiratory‐system resistance, reactance and reactance area (AX) measurements in 175 participants including 42 never ‐smokers without respiratory disease, 56 ex‐smokers with chronic‐obstructive‐pulmonary‐disease (COPD), 28 ex‐smokers without COPD and 49 asthmatic never‐smokers. COPD participants were dichotomized based on x‐ray computed‐tomography (CT) evidence of emphysema (relative‐area CT‐ density‐histogram ≤ 950HU (RA950) ≥ 6.8%). In asthma and COPD subgroups, MRI VDP was...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research