Lupin developing new products to treat cancer, other diseases

Sharing details, Kamboj said the the Mumbai-based company is currently working on developing various products, including two major ones to treat chronic kidney diseases and lung cancer.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

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BackgroundThe survival outcomes of lung cancer patients with coexisting chronic kidney disease (CKD) reported in the literature have been conflicting. We evaluate whether the survival of lung cancer patients with and without CKD differ significantly using two different formulas.MethodsA retrospective, multicenter, propensity ‐matched study of lung cancer patients with and without CKD was conducted. CKD was defined as an estimated glomerular filtration rate (eGFR)
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
IntroductionBased on improvement of overall survival (OS), lenalidomide (R) maintenance after up-front autologous stem cell transplantation has recently been approved for multiple myeloma (MM) patients (pts). Conversely, in transplant non-eligible (TNE) pts R maintenance after R-based induction improved progression free survival (PFS) but had no impact on OS. First-line treatment with VMP is considered a standard of care for newly diagnosed (ND) TNE pts, but whether maintenance therapy with R after VMP induction can further improve PFS and OS is currently unknown.AimsThe prospective phase IIb GERMAIN trial (EudraCT-No: 201...
Source: Blood - Category: Hematology Authors: Tags: 653. Myeloma: Therapy, excluding Transplantation: Poster I Source Type: research
Tuberculosis (TB) is a mandatory notification disease, with a free care policy for patients in treatment.Criteria for TB patients’ hospitalization are often: severe disease, comorbidities management, drug toxicity, multidrug resistance or other factors that can impair treatment.We aimed to evaluate the impact of hospitalization on TB outcome.We performed a retrospective study of all TB cases registered on the National Surveillance TB Program between 2008 and 2013 which were cross linked with all inpatients with a TB diagnosis. Data was collected on demographic variables, comorbidities, risk factors, TB disease charac...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Conclusion: This study emphasizes the impact of comorbidities and its real burden in COPD. For better outcomes and quality of life each comorbidity should be individually assessed and treated
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Optimal survival benefit from different lines of anticancer treatment in advanced nonsmall cell lung cancer (NSCLC) requires conservation of renal function. We evaluated the development of renal impairment during pemetrexed maintenance. In a prospective multicentre cohort study, we evaluated the incidence of acute/chronic kidney disease (AKD/CKD), its related treatment discontinuation frequency and associated clinical variables with AKD in patients with stage IIIB/IV NSCLC treated with pemetrexed maintenance. We validated the findings in an independent cohort. 190 patients received pemetrexed. In the primary cohort, 149 pa...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Lung cancer Source Type: research
CONCLUSION: Low back and neck pain was the most important contributor of disability in Spain in 2016. There has seen a remarkable increase in the burden due to Alzheimer disease and other dementias. Tobacco remains the most important health issue to address in Spain. PMID: 30037695 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
In conclusion, in our study of all the VTE–RAMs analyzed, the COMPASS-CAT model was the most accurate predictor of VTE development in patients with lung cancer.
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThe eGFR calculated by the CKD-EPI equation changed more significantly between each chemotherapy cycle than did the eGFR from the other equations based on Scr or CysC in patients with SCLC. Oncologists should pay more attention to the renal function of specific patient groups during treatment.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Abstract PurposeEvaluate changes in use of erythropoiesis‐stimulating agents (ESAs) and red blood cell transfusion in cancer patients receiving myelosuppressive chemotherapy following regulatory and reimbursement actions. MethodsCalendar year patient cohorts (2005‐2013) with breast, colorectal, lung, multiple myeloma, non‐Hodgkin lymphoma, ovarian, or prostate cancer and receiving myelosuppressive chemotherapy were identified within the Marketscan database. Incidence of ESA treatment and transfusion were estimated in each year, as was median number of ESA administrations. Clinical characteristics associated with ESA ...
Source: Pharmacoepidemiology and Drug Safety - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL REPORT Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Mini Review Source Type: research
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