Leukemia inhibitory factor represses GnRH gene expression via cFOS during inflammation in male mice

Conclusion: Our results indicate that the increase in LIF due to neuroinflammation induces cFOS and represses GnRH gene. Therefore, in addition to synaptic changes in GnRH neurons, neuroinflammatory cytokines directly regulate gene expression and reproductive fun ction, and the specificity for neuronal targets may stem from the proximity to the fenestrated capillaries.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research