How to ship a dead heart . . . with an assured life on delivery ?

Human body is intertwined collection of lives of Individual organs.We believe death occurs when brain dies , respiration stops and circulation ceases . Curiously ,when life ends , these organs  don’t die as a single unit . These three events can happen in any of the six possible permutations.Each organ takes different times to die after loss of life.It is like a crashed computer , where the mother board /RAM memory may be transferred to another and be functional . Out of these three , heart function appears to be supreme as it can function without the need of brain (Science of brain-death) and keep the body alive with intact circulation. Though the concept  called heart dead organ donors is catching up as well. (John Gill et all Use and Outcomes of Kidneys from Donation after Circulatory Death Donors in the United States    JASN Dec 2017, 28 (12) 3647-3657) The science of organ transplant has rapidly  evolved .We can transfer an organ from one who is dying or dead to another person who is also dying due to failure of a different organ. Though most organs can be transported and transplanted , we need to maintain life in a dead donor organ . A new and curious specialty  in medicine is emerging which could be named a  Critical Care of Dead or Critical Cadaveric Care Units !) till harvesting happens. Paradoxically ,after the harvest , the organ gains independent  life that has to be su...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Heart transplantation donor heart transport transmedics Source Type: blogs

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsHypothalamic EPO plays a role in the central regulation of muscle and metabolic physiology while its decline contributes to aging and obesity physiology in a manner which is independent of peripheral EPO.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
In this study, we focus on the analysis of sharing variances which allow allocating organs within participating members before offering them at other levels. This type of variance has been successfully implemented in the past. For example, Florida and Tennessee created the Statewide Sharing program whereby kidneys are made available within-state donor service areas before they are made available for regional or national allocation. This program removed geographic disparities within those two states and resulted in better performance of the system in the states. Given these success stories, we propose a multi-period optimiz...
Source: Operations Research for Health Care - Category: Hospital Management Source Type: research
We describe the phenotype of the Prodh2 knock out mouse model and show that the lack of HYPDH in PH mouse models results in lower levels of urinary oxalate excretion, consistent with our previous metabolic tracer and siRNA-based knockdown studies. The double knockout mouse, Grhpr KO (PH2 model) and Prodh2 KO, prevented calcium-oxalate crystal deposition in the kidney, when placed on a 1% Hyp diet. These observations support the use of the Grhpr KO mice to screen HYPDH inhibitors in vivo. Altogether these data support HYPDH as an attractive therapeutic target for PH2 and PH3 patients.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
ConclusionThe combination of donor sCr and Δγ-H2AX from 0 to 1 h after reperfusion may predict severe DGF and PNF in the early phase.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
AbstractBackgroundHigh prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.MethodsThis retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.ResultsAt discharge and 3 years post-transplant, arterial hypertension ...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conditions:   Diabetes;   Diabetes Mellitus Interventions:   Device: Artificial Pancreas;   Other: Multiple Daily Injections Sponsor:   University of Virginia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Researchers have made considerable progress in the construction of small, functional tissue sections called organoids over the past decade, enabled by a combination of better understanding the mechanisms involved in regeneration and embryonic development of tissues, advances in 3-D bioprinting, guidance of cell behavior via appropriate provision of signal molecules, and the generation of environments that mimic an existing tissue environment. Every tissue requires its own specific recipe of signals and environment in order to form a functional organoid, but researchers have demonstrated the manufacture of organoids for liv...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: Available online 5 December 2019Source: American Journal of Kidney DiseasesAuthor(s): Sanjay Kulkarni, Guo Wei, Wei Jiang, Licia A. Lopez, Chirag R. Parikh, Isaac E. HallRationale &ObjectiveThere may be important transplant-related differences between right and left kidneys, including logistical/surgical considerations about vessel length for the right compared to the left kidney from the same donor. Because US centers choose between the right and left kidney when their recipient is ranked higher on a “match-run,” we sought to determine whether deceased-donor right kidneys have had worse p...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsWith regard to KT patients and sterile wound dressing fixation with non-sterile bandages versus the use of autoclaved bandages, fixation with autoclaved bandages proved to be effective for cutaneous mucormycosis outbreak control and prevention in our institution.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
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