RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3 ß and JNK signaling pathways in dopaminergic neuron-like cells.

In conclusion, the present study indicates that DJ-1 knockdown leads to mitochondrial dysfunction in dopaminergic neuron-like cells, at least in part, through suppressing the Akt/GSK3β pathway and impairing the oxidative stress response, as well as through the subsequent increased JNK activation in dopaminergic neuron-like cells.
PMID: 30634017 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - January 8, 2019 Category: Neurology Authors: Zhang XL, Wang ZZ, Shao QH, Zhang Z, Li L, Guo ZY, Sun HM, Zhang Y, Chen NH Tags: Brain Res Bull Source Type: research