Spatio-temporal image correlation (STIC) in evaluation of advanced neuroendocrine tumors.

CONCLUSION: HDF STIC seems not to be an efficient marker to assess advancement of NENs due to lack of correlation with widely used and approved markers of progression. BACKGROUND: 4D Ultrasound technology merging Power Doppler option called High Definition Flow (HDF) with Spatio-Temporal Image Correlation (STIC) is used in gynecology and obstetrics. It seems to be a promising tool in assessing tissue vascularization. AIM: To assess whether HDF STIC technique could be a useful tool for evaluation of gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) advancement. METHOD: Forty-eight patients (mean age 57.7 10.3 years; male 40.9% (n=18)) diagnosed with metastatic GEP-NENs were included to analysis. All subjects were enrolled in the Department of Endocrinology and Neuroendocrine Tumors, Medical University of Silesia, Katowice. We analyzed liver metastases. Patients with G3 grading or faintly vascularized lesions were excluded. HDF STIC volumes were acquired during USG examination. 4D indices (Volumetric Pulsatility Index (vPI) and Volumetric Systolic/Diastolic Index (vS/D)) were calculated using dedicated software. RESULTS: There were no correlations between vS/D and Ki67 (P=0.67; r= -0.19; (-0.28- 0.19)), CgA (P=0.47; r= -0.11; (-0.38- 0,19)), 5-HIAA (P=0.52; r= -0.09 (-0.37- 0.2)), serotonin (P=0.83; r= -0.03 (-0.32- 0.26)), VCAM-1 (P=0.62; r= 0.09 (-03- 0.47)). The were no correlations between vPI and Ki67 (P=0.29; r= -0.16 (-0.45- 0.1...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research