Improving dosimetric outcome for hippocampus and cochlea sparing whole brain radiotherapy using spot-scanning proton arc therapy.

Improving dosimetric outcome for hippocampus and cochlea sparing whole brain radiotherapy using spot-scanning proton arc therapy.
Acta Oncol. 2019 Jan 11;:1-8
Authors: Ding X, Zhou J, Li X, Blas K, Liu G, Wang Y, Qin A, Chinnaiyan P, Yan D, Stevens C, Grills I, Kabolizadeh P
Abstract
This feasibility study shows that Spot-scanning Proton Arc therapy (SPArc) is able to significantly reduce the dose to the hippocampus and cochlea compared to both Volumetric Modulated Arc Photon Therapy (VMAT) and the robust optimized Intensity Modulated Proton Therapy (ro-IMPT) plans in whole brain radiotherapy. Furthermore, SPArc not only improves plan robustness but could potentially deliver a treatment as efficient as ro-IMPT when proton system's energy layer switch time is less than 1 s.
PMID: 30632851 [PubMed - as supplied by publisher]

Source: Acta Oncologica - January 11, 2019 Category: Cancer & Oncology Authors: Ding X, Zhou J, Li X, Blas K, Liu G, Wang Y, Qin A, Chinnaiyan P, Yan D, Stevens C, Grills I, Kabolizadeh P Tags: Acta Oncol Source Type: research