Counting Footsteps with a Pedometer to Improve HMW Adiponectin and Metabolic Syndrome among Young Female Adults in the United Arab Emirates.

This study examined how counting footsteps, using a pedometer, might affect HMW-Adip and MetS components among young females. Methods: Fifty-two females (21.43 ± 4.8 years) were divided into "normal" (BMI = 18-24.9 kg/m2) and "high" (BMI ≥ 25 kg/m2) BMI groups. Participants wore pedometers throughout the day for nine weeks. Pre-post intervention tests performed on anthropometric, biochemical, and nutrient intake variables were tested at p ≤ 0.05. Results: Participants walked 7056 ± 1570 footsteps/day without a significant difference between normal (7488.49 ± 1098) and high (6739.18 ± 1793) BMI groups. After week 9, the normal BMI group improved significantly in BMI, body fat mass (BFM), and waist-hip ratio (WHR). Additionally, percent body fat, waist circumference (WC), and visceral fat area also reduced significantly in the high BMI group. A significant decrease in triglycerides (TG) (71.62 ± 29.22 vs. 62.50 ± 29.16 mg/dl, p=0.003) and insulin (21.7 ± 8.33 µU/l vs. 18.64 ± 8.25 µU/l, p=0.046) and increase in HMW-Adip (3.77 ± 0.46 vs. 3.80 ± 0.44 μg/ml, p=0.034) were recorded in the high BMI group. All participants exhibited significant inverse correlations between daily footsteps and BMI (r=-0.33, p=0.017), BFM (r=-0.29, p=0.037), WHR (r=-0.401, p=0.003), and MetS score (r=-0.49, p
Source: Journal of Obesity - Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research

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This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we investigated the effect of trehalose on the development of NASH in the Tsumura Suzuki Obese Diabetes (TSOD) mouse, a metabolic syndrome model characterized by obesity, type 2 diabetes, and NASH. We found that trehalose intake markedly inhibited histopathological features of NASH, particularly hepatic steatosis and liver cell injury, in TSOD mice. Trehalose intake attenuated increase in mesenteric adipose tissue weight, impaired glucose tolerance, and iron deposition in the duodenum, suggesting that trehalose prevents insulin resistance and iron absorption in TSOD mice. These findings indicate that trehalo...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 23 March 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Gloribel A. Bonilla, Paige P. Hornsby, Aaron F. Pannone, Samuel K. Case, Emerson S. Aviles, Magdeline E. Carrasco Apolinario, Desideria Mercedes, Aura Mota, Ammar IbrahimAbstractAimTo identify the demographic and clinical characteristics of Dominican adults admitted to a diabetic foot clinic and compare these characteristics by sex to better characterize and understand the severity of diabetes in the Dominican Republic.MethodsWe conducted a retrospective medical chart review of Dominican adults...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Oliver D. John, Peter Mouatt, Indira Prasadam, Yin Xiao, Sunil K. Panchal, Lindsay BrownAbstractDavidson’s plum is a native Australian fruit used traditionally as food and medicine. The fruit contains anthocyanins as glucosides and sambubiosides of cyanidin and peonidin (691 mg/100 g of dried pulp) with rutin and quercetin glycosides (193 mg/100 g). Dietary supplementation of Davidson’s plum at approximately 8 mg anthocyanins/kg/day in rats attenuated the signs of metabolic syndrome induced by high-carbohydrate, high-fa...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
ConclusionWe found that adherence to DASH was inversely associated with odds of MetS and some of its components including elevated blood pressure, low serum HDL-C and high serum triglyceride.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
CONCLUSION: Soldiers in this study had higher body fat percentages than expected with a majority of Soldiers classified as obese. Achieving and maintaining ABCP standards may be more challenging for obese Soldiers. To maintain Soldier readiness, commanders should consider intervening earlier when signs of weight gain are observed. PMID: 30901401 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Conclusion: Therefore, considering the role of myonectin in increasing fatty acid uptake, exercise training can play an essential role in decreasing obesity-related diseases and metabolic syndrome; this effect is partly related to the roles of myonectin. Therefore, the use of this type of exercise is recommended to reduce the risk of diseases associated with obesity and metabolic syndrome. PMID: 30894898 [PubMed - in process]
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
With a high incidence of insulin resistance, central obesity and dyslipidemia, polycystic ovary syndrome (PCOS) women are susceptible to metabolic syndrome (MetS). Our objective was to explore whether MetS had an effect on overall female fertility and in vitro fertilization (IVF) outcomes in PCOS infertile women.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Source Type: research
ConclusionHigher intakes of total polyphenols and flavonoids were inversely associated with BMI. No consistent associations were found for other MetS components.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Abstract There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus addressed the potential role of defective mitophagy in the pathogenesis of metabolic disorders. Mice lacking Fundc1, a newly characterized mitophagy receptor, develop more severe obesity and insulin resistance when fed a high-fat diet (HFD). Ablation of Fundc1 results in defective mitophagy a...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
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