A metabolomic explanation on beneficial effects of dietary Goji on intestine inflammation

This study profiled faecal metabolomic changes of the same cohort of mice. Thirty-four compounds were altered due to Goji supplementation, including polyunsaturated long-chain fatty acids (PUFAs), sugar and sugar alcohols, benzene derivatives, pyridine derivatives, dicarboxylic acids and short-chain hydroxy acids. Pathway analysis showed that α-linolenic acid and linoleic acid metabolism were strongly affected by Goji supplementation. Four ω-6 PUFAs, including linoleic acid and arachidonic acid were reduced due to Goji supplementation. Faecal levels of most amino acids, positively correlated with gut inflammation and CRC risk, tended to decrease in the Goji supplemented group along with decreased urease activity. Data provide valuable metabolic clues for unravelling the beneficial effects of Goji supplementation against gut inflammation and related disease.Graphical abstractDietary Goji berry promotes probiotics and decreases ω-6 polyunsaturated fatty acids (PUFAs) and amino, acids of gut metabolites in IL-10 deficient mice, conferring preventative effects against gut inflammation, and related gut diseases.
Source: Journal of Functional Foods - Category: Nutrition Source Type: research