Tumor-suppressive effects of microRNA-181d-5p on non-small-cell lung cancer through the CDKN3-mediated Akt signaling pathway in vivo and in vitro.

In conclusion, this study highlights the tumor suppressive effects of miR-181d-5p on NSCLC via Akt signaling pathway inactivation by suppressing CDKN3, providing a promising therapeutic strategy for the treatment of NSCLC.
PMID: 30628487 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - January 10, 2019 Category: Cytology Authors: Gao LM, Zheng Y, Wang P, Zheng L, Zhang WL, Di Y, Chen LL, Yin XB, Tian Q, Shi SS, Xu SF Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research