Coumarins isolated from Calophyllum brasiliense produce ultrastructural alterations and affect in vitro infectivity of Trypanosoma cruzi.

ConclusionMammea A/BA (93.6%) and a mixture of mammea A/BA+ A/BB and A/BD (86: 10: 1%) isolated from the tropical tree C. brasiliense showed higher trypanocidal activity than the current drug benznidazole on three Mexican strains of T. cruzi. These compounds induced severe physiological and morphological alterations. These results suggest their possible use in preclinical studies.Graphical abtract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research